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KMID : 0903520090520050564
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2009 Volume.52 No. 5 p.564 ~ p.567
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The Anti-Melanogenic Effects of Petalonia binghamiae Extracts in α-Melanocyte Stimulating Hormone-Induced B16/F10 Murine Melanoma Cells
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Yoon Hoon-Seok
Koh Won-Beom
Oh You-Sung
Kim In-Jung
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Abstract
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Petalonia binghamiae extracts (PBE) suppressed melanin synthesis in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-treated B16/F10 murine melanoma cells. Specifically, the cell tyrosinase activity and melanin content were inhibited by 72% and 48%, respectively, in response to treatment with 100 μg/mL of PBE. The results of western blot analysis suggest that PBE induced the inhibition of tyrosinase and TRP-1 protein expression through suppression of α- MSH induced p38 and ERK activation.
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KEYWORD
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depigmentation, melanin, Petalonia binghamiae, tyrosinase
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